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Backup/Restore for large data (hundreds of TB)

My prospect wants to backup large genomic data (500TB) from the point of view of operation mistakes.
The genomic data is not updated frequently. Do we generally back up it to shared volumes using Vbr.py? Could you give me your recommendation for this scale?
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Is this env on prem or public cloud ?
Hi Ganesh_2,
This environment is on prem.